pentobarbital will reduce the extent or result of abemaciclib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Coadministration of abemaciclib with solid CYP3A4 inducers decreases plasma focus of abemaciclib and its metabolites.Warning is warranted for individuals with renal and hepatic impairment. Whil